Tirzepatide is a medication that was developed primarily for the treatment of type 2 diabetes.
However, it has shown promising results for weight loss and is now being considered as an option for managing obesity. It’s marketed under the brand name Mounjaro for diabetes management and has also been studied for weight loss in clinical trials.
It’s an injectable medication, but you’re specifically asking about oral tablets, which is the newer form for easier administration.
While tirzepatide is available as an injectable medication (Mounjaro), the sublingual tablet version would offer an alternative way of administration. This type of formulation would aim to deliver the drug through the tissues under the tongue, allowing it to be absorbed directly into the bloodstream without going through the digestive system.
One of the key mechanisms through which tirzepatide helps with weight loss is appetite reduction.
By improving insulin sensitivity, tirzepatide can also help in managing prediabetes or diabetes, which are often related to obesity.
Oral tablets of tirzepatide are an attractive option for those who prefer not to use injectable medications, making weight management easier for more people.
Formulation Issues:- Tirzepatide is a large peptide molecule, and delivering large peptides like tirzepatide via the sublingual route presents significant challenges.
Stability: Ensuring the drug remains stable and effective in a sublingual tablet form is a complex process. Peptide drugs like tirzepatide might degrade more quickly when exposed to air, moisture, or other environmental factors.
The oral form of tirzepatide is designed to provide the same benefits as the injectable version. Oral tablets may be more convenient for individuals who prefer not to inject themselves.
The oral formulation is still relatively new and is considered an innovation in diabetes care.
Type 2 Diabetes: Tirzepatide is mainly used to improve blood sugar control in people with type 2 diabetes, alongside diet and exercise.
Weight Loss: One of the significant benefits of tirzepatide observed in clinical trials is weight loss, making it attractive for managing obesity in patients with type 2 diabetes.
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